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The aminoalkylindole WIN 55,212-2 is used to make JWH 018, a somewhat selective agonist of the peripheral cannabinoid (CB2) receptor in humans. For a CB1:CB2 ratio of 3.061, the Ki values for binding to the CB1 and CB2 receptors, respectively, are 9.0 and 2.94 nM. Tests were conducted on rats, and the findings regarding rectal temperature, maximum antinociceptive impact in the tail-flick experiment, and inhibition of spontaneous activity were similar to those of WIN 55,212-2.JWH 018 powder sales online in the United States

Available in the US is JWH-018.

Animal pharmacology studies suggest that 018 tablet functions similarly to 9-THC. It causes analgesia, a lowering of body temperature, catalepsy, and a general decrease in activity in mice. When these four impacts are combined, There is no known scientific predictor of human psychoactivity similar to that of 9-THC. Based on JWH-018’s results in all four tests, it is likely that people will experience psychoactive effects similar to those of THC. JWH-018 generalized to 9-THC and caused subjective reactions comparable to 9-THC in rat experiments on drug discrimination. JWH-018 exhibits agonist qualities in functional tests and binds to the brain cannabinoid receptor CB1 with more affinity than 9-THC, indicating that it may have functions comparable to those of 9-THC in vivo.

USA-based internet retailer offering JWH 018 powder. We provide multiple variations of the “Spice” herbal blend. Due to its synthetic cannabinoid’s intoxication properties, which resemble those of 9-THC in cannabis, Most of its use is illicit. Although jwh 018 has a much higher potency than comparable cannabis dosages, it is also very difficult to identify using standard 9-THC testing techniques. JWH-018 was added to the US Drug Enforcement Agency’s (DEA) list of substances and compounds of concern in July 2009. Aside from stories of Spice seizures in Florida and Ohio, laws prohibiting the sale or possession of JWH-018 powder have been approved in Alabama, Arkansas, and Florida, among other places.